Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 23;9(2):315–326. doi: 10.3233/JPD-191590

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 – IOS Press and the authors. All rights reserved

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Fig.1 — Inducing α-syn pathology in En1⁺^/– mice. Engrailed1 expression is vital for CNS development and maintenance, particularly for nigrostriatal projections. A) En1⁺^/– mice feature a LacZ insertion cassette in one allele and feature B) progressive “dying-back” nigrostriatal degeneration, dysfunctional mechanisms in the autophagy-lysosomal pathway, and pathologic neuroinflammatory activation. En1⁺^/– mice also feature mitochondrial respiratory chain perturbations and motor dysfunction associated with PD clinical pathology [7, 9]. C) Human pre-formed α-syn fibrils were sonicated, validated by TEM, and injected into the dorsal striatum. D) PFF injection causes robust phosphorylated-serine129 α-syn (pS129) deposition at the site of injection. E) Both WT and En1⁺^/– animals were unilaterally injected at one month of age and sacrificed for post-mortem histology eight weeks following PFF injection.