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Pathological propagation of α-Syn is enhanced throughout En1+/– neuraxis. A) Schematic representation of brain regions depicting sites of observed pathological α-syn (pS129 labeled) cellular and neuritic deposition. B) Heat map representing semi-quantititative pS129-pathological scores across numerous regions in both WT and En1+/– mice injected with striatal PFFs (N = 8). Regions were assessed both ipsilateral and contralateral to PFF injection.
