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. 2019 Jun 21;10:1354. doi: 10.3389/fimmu.2019.01354

Figure 3.

Figure 3

NK cell dysfunction correlates with clinical outcome in PC. (A) The malignant group was divided into resectable and unresectable subgroups. PBMCs from the resectable group (n = 16) and the unresectable group (n = 15) were incubated with or without the indicated target cells, as described in Figure 1 (circle, resectable; square, unresectable). In each group, NK cell surface expression of CD107a and intracellular expression of IFN-γ were compared. (B) The unresectable group was subdivided into living (n = 10) or deceased (n = 5) patients at 6 months after diagnosis. The NK cell activity of each subgroup was compared. (C) The resectable group was subdivided into patients with (n = 11) or without (n = 5) recurrence at 6 months after surgical resection. The NK cell activity of each subgroup was compared. (D) The resectable group was subdivided into patients with (n = 9) or without (n = 7) recurrence at 12 months after surgical resection. Horizontal bars (green) indicate the medians. *P < 0.05 and **P < 0.01; Mann-Whitney U-test.