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. 2019 Jun 21;10:1354. doi: 10.3389/fimmu.2019.01354

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Copyright © 2019 Jun, Song, Choi, Lee, Kim, Ko, Kang, Kim, Bryceson, Kim and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between the level of TGF-β1 and impaired NK cytotoxicity in PC patients. (A) The plasma levels of TGF-β1 and IL-6 were measured by Luminex multiplex assay. Plasma levels of the indicated cytokines in the healthy control (HC) group (n = 18), the non-malignant group (n = 19), and the malignant group (n = 26). Horizontal bars denote the medians. (B) Plasma TGF-β1 levels in the malignant group correlated inversely with the percentages of CD107a-positive NK cells after stimulation with P815-ULBP1+CD48 cells. **P < 0.01 and ***P < 0.001; Kruskal-Wallis with Dunn's test (A) and Spearman's correlation test (B).