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. 2019 Jun 18;69(4):1171–1182. doi: 10.3233/JAD-180525

Fig.2.

Fig.2

Neuropsychological decline predicts dementia beyond AD biomarkers. Cox regression models predicting progression to dementia over all follow-up by cognitive diagnosis without neuropsychological decline (CN dashed blue; MCI dashed red) versus those cognitive diagnosis with neuropsychological decline (CN solid blue; MCI solid red) for each biomarker profile, including normal AD biomarkers, Aβ-Ptau- (A: n = 276, MMSE = 28.7[1.4]), AD pathophysiology, Aβ+Ptau- (B: n = 148, MMSE = 28.4[1.6]), suspected non-AD pathophysiology, Aβ-Ptau+(C: n = 120, MMSE = 28.5[1.5]), and AD, Aβ+Ptau+(D: n = 214, MMSE = 27.7[1.8]). Mean[SD].