Table 1.

Thematic summary of barriers (–) and facilitators (+) to recruitment

Theme	Barriers (–)	Facilitators (+)
1. System	AD diagnostic pathway	linking up systems with other sites
	poor record keeping and quality of information (local)	establish links with other services and recruitment avenues
	research not embedded in culture of AD care	make research part of standard treatment options
	lack of/inaccurate information on national database	multiple staff members using national database
	resources needed to use the national database
	self-selected nature of patients on national database
2. Healthcare Professionals	gate-keeping	personal knowledge/direct contact
	lack of connection with other sites	good links with other researchers/sites
		staff training
3. Patient and companions	requirement for research partner/companion	presentation of clear, simple and concise information
	research partner/companion acting as a gate-keeper	follow-up with patient
	overly complex/unnecessarily detailed language/materials	prior patient involvement in research
	insufficient information on key topics	patient belief in the trial and its benefits
	concerns for clinical condition and prolonged participation
	preference for active arm