Table 2. Peak-to-trough ratios (95% confidence intervals) of summarized monthly cases during 1977–2016 (deep vein thrombosis, pulmonary embolism, provoked VTE, unprovoked VTE, and splanchnic vein thrombosis) and during 1994–2016 (cerebral vein thrombosis and retinal vein thrombosis).
| Deep venous thrombosis | Pulmonary embolism | Provoked VTE | Unprovoked VTE | Splanchnic venous thrombosis | Cerebral venous thrombosis | Retinal venous thrombosis | |
|---|---|---|---|---|---|---|---|
| All patients | 1.09 (1.07–1.11) | 1.22 (1.19–1.24) | 1.15 (1.13–1.18) | 1.13 (1.11–1.15) | 1.10 (1.01–1.20) | 1.19 (1.00–1.40) | 1.12 (1.07–1.17) |
| Women | 1.06 (1.03–1.09) | 1.23 (1.20–1.27) | 1.15 (1.11–1.18) | 1.11 (1.08–1.14) | 1.30 (1.10–1.53) | 1.11 (1.00–1.38) | 1.08 (1.01–1.15) |
| Men | 1.13 (1.10–1.16) | 1.20 (1.17–1.23) | 1.16 (1.12–1.19) | 1.16 (1.13–1.19) | 1.17 (1.00–1.35) | 1.12 (1.00–1.47) | 1.15 (1.08–1.23) |
| Age groups, y | |||||||
| 0–29 | 1.05 (1.00–1.14) | 1.25 (1.11–1.40) | 1.08 (1.00–1.22) | 1.11 (1.03–1.19) | 1.09 (1.00–1.75) | 1.23 (1.00–1.67) | 1.06 (1.00–1.78) |
| 30–49 | 1.05 (1.01–1.10) | 1.06 (1.00–1.13) | 1.09 (1.02–1.16) | 1.08 (1.04–1.12) | 1.24 (1.00–1.60) | 1.09 (1.00–1.50) | 1.20 (1.01–1.42) |
| 50–69 | 1.10 (1.07–1.13) | 1.23 (1.19–1.27) | 1.16 (1.12–1.21) | 1.14 (1.11–1.18) | 1.30 (1.09–1.54) | 1.10 (1.00–1.52) | 1.12 (1.04–1.20) |
| 70+ | 1.17 (1.13–1.20) | 1.25 (1.22–1.29) | 1.17 (1.13–1.20) | 1.23 (1.20–1.26) | 1.04 (1.00–1.26) | 1.11 (1.00–1.71) | 1.10 (1.03–1.17) |
| Charlson Comorbidity Index score | |||||||
| 0 | 1.13 (1.11–1.16) | 1.25 (1.21–1.28) | 1.22 (1.18–1.27) | 1.16 (1.14–1.18) | 1.10 (1.00–1.32) | 1.16 (1.00–1.44) | 1.09 (1.03–1.16) |
| 1 | 1.08 (1.03–1.13) | 1.20 (1.14–1.26) | 1.11 (1.04–1.18) | 1.11 (1.07–1.15) | 1.27 (1.00–1.67) | 1.19 (1.00–1.74) | 1.16 (1.05–1.29) |
| 2 | 1.03 (1.00–1.08) | 1.17 (1.11–1.23) | 1.12 (1.08–1.17) | 1.05 (1.00–1.12) | 1.01 (1.00–1.34) | 1.07 (1.00–1.85) | 1.07 (1.00–1.21) |
| 3+ | 1.01 (1.00–1.06) | 1.19 (1.14–1.25) | 1.11 (1.06–1.15) | 1.06 (1.00–1.14) | 1.34 (1.01–1.63) | 1.03 (1.00–1.82) | 1.17 (1.03–1.33) |
| Calendar period | |||||||
| 1977–1993 | 1.17 (1.13–1.21) | 1.23 (1.20–1.28) | 1.18 (1.14–1.22) | 1.22 (1.18–1.26) | 1.04 (1.00–1.21) | NA | NA |
| 1994–2008 | 1.07 (1.04–1.11) | 1.19 (1.15–1.24) | 1.13 (1.09–1.17) | 1.10 (1.07–1.13) | 1.15 (1.00–1.37) | 1.08 (1.00–1.36) | 1.07 (1.01–1.14) |
| 2009–2016 | 1.04 (1.01–1.08) | 1.22 (1.18–1.26) | 1.14 (1.10–1.18) | 1.09 (1.05–1.12) | 1.20 (1.04–1.39) | 1.29 (1.01–1.65) | 1.16 (1.08–1.23) |
| Type of diagnosis | |||||||
| Primary | 1.09 (1.07–1.11) | 1.22 (1.20–1.25) | 1.15 (1.12–1.18) | 1.13 (1.11–1.15) | 1.12 (1.00–1.26) | 1.10 (1.00–1.32) | 1.11 (1.06–1.17) |
| Secondary | 1.10 (1.06–1.15) | 1.20 (1.16–1.24) | 1.15 (1.11–1.19) | 1.15 (1.11–1.19) | 1.03 (1.00–1.18) | 1.09 (1.00–1.57) | 1.12 (1.02–1.24) |
| Department | |||||||
| Inpatient | 1.10 (1.08–1.12) | 1.22 (1.19–1.24) | 1.15 (1.13–1.18) | 1.14 (1.12–1.26) | 1.04 (1.00–1.15) | 1.20 (1.00–1.43) | 1.05 (1.00–1.33) |
| Outpatient | 1.08 (1.03–1.13) | 1.23 (1.13–1.33) | 1.18 (1.10–1.27) | 1.09 (1.04–1.15) | 1.23 (1.00–1.62) | 1.06 (1.00–1.70) | 1.11 (1.06–1.16) |
| Plasmode simulation a | 1.05 (1.03–1.07) | 1.09 (1.07–1.11) | 1.06 (1.04–1.09) | 1.06 (1.05–1.09) | 1.05 (1.00–1.14) | 1.13 (1.00–1.31) | 1.07 (1.03–1.12) |
Abbreviations: NA, not applicable; VTE, venous thromboembolism (deep venous thrombosis and pulmonary embolism).
a
Mean peak-to-trough ratio from random reassignment of monthly cases 1000 times.