Table 1.
Characteristics of the Study Population.
| Variable | Patients or Mean |
|---|---|
| Total patient number | 100 |
| Age at surgery (years) | 69.4 (range: 37.5–96.2) |
| Primary site of the tumor | |
| Vulva | 100 |
| Histology | |
| SCC | 94 |
| SCC in situ | 2 |
| SCC microinvasive | 3 |
| Verrucous carcinoma | 1 |
| Grade | |
| I | 38 |
| II | 39 |
| III | 19 |
| Unknown | 4 |
| HPV statusa | |
| HPV positive | 27 |
| HPV negative | 73 |
| Local recurrence | 11 |
| Lymph node metastasis | 28 |
Abbreviations: SCC, squamous cell carcinoma; HPV, human papilloma virus.
a
Estimation of HPV status by p16INK4A immunostaining. Tissue samples with >25% tumor cell positivity for p16INK4A were considered to be HPV positive.