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. 2019 Jun 21;10:705. doi: 10.3389/fphar.2019.00705

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Copyright © 2019 Costa-Ferreira, Morais-Silva, Gomes-de-Souza, Marin and Crestani

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Depressive-like state in animals treated with either vehicle or losartan control (white bars) and subjected to RRS (gray bars) or CVS (black bars). (A) Sucrose preference (%) evaluated during 3 and 24 h. *P < 0.05 versus respective control group, two-way ANOVA (n = 10/group). (B) Coat state score. *P < 0.05 versus respective control group, two-way ANOVA (n = 10/group). (C) Body weight at the 10^th day of stress protocol. Two-way ANOVA (n = 10/group). The bars in all graphs represent the mean ± SEM.