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. 2019 Jun 21;10:1211. doi: 10.3389/fimmu.2019.01211

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Copyright © 2019 Costa-Rocha, Campi-Azevedo, Peruhype-Magalhães, Coelho-dos-Reis, Fradico, Souza-Lopes, Reis, Freire, Costa-Pereira, Mambrini, Maia, Lima, Noronha, Xavier, Camacho, Albuquerque, Farias, Castro, Homma, Romano, Domingues, Martins, Teixeira-Carvalho and Martins-Filho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biomarker network matrices 8-years after 17DD-YF primary vaccination with different doses. The biomarker network of YF-specific humoral and cellular memory was built to define the connections between PRNT levels (log₁₀ mIU/mL), phenotypic (NCD4, eEfCD4, CMCD4, EMCD4, NCD8, eEfCD8, CMCD8, EMCD8, NCD19, nCMCD19, and CMCD19) and functional memory attributes (TNFCD4, IFNCD4, IL10CD4, IL5CD4, TNFCD8, IFNCD8, IL10CD8, IL5CD8, TNFCD19, IL10CD19, and IL5CD19). Correlation analysis were carried out for six vaccinees groups, according to the dose of 17DD-YF vaccine administered in 2009: 27,476IU, considered the reference dose; 10,447IU; 3,013IU; 587IU; 158IU, and 31IU. Matrices were assembled in dotted template with each dot representing a correlation axis between two attributes. Color keys were employed to identify significant Spearman's correlation “r” indices at p < 0.05, referred as positive (red scale, , r(+) ranging from 0.5 to 1.0) or negative (green scale, , r(-) ranging from −1.0 to −0.5). Non-significant correlations are represented by white dots. Ratio between positive and negative correlations “r(+)/r(-)” are provided in the Figure. The common correlations across distinct 17DD-YF vaccine doses are highlighted by orange frames.

Inline graphic — Biomarker network matrices 8-years after 17DD-YF primary vaccination with different doses. The biomarker network of YF-specific humoral and cellular memory was built to define the connections between PRNT levels (log₁₀ mIU/mL), phenotypic (NCD4, eEfCD4, CMCD4, EMCD4, NCD8, eEfCD8, CMCD8, EMCD8, NCD19, nCMCD19, and CMCD19) and functional memory attributes (TNFCD4, IFNCD4, IL10CD4, IL5CD4, TNFCD8, IFNCD8, IL10CD8, IL5CD8, TNFCD19, IL10CD19, and IL5CD19). Correlation analysis were carried out for six vaccinees groups, according to the dose of 17DD-YF vaccine administered in 2009: 27,476IU, considered the reference dose; 10,447IU; 3,013IU; 587IU; 158IU, and 31IU. Matrices were assembled in dotted template with each dot representing a correlation axis between two attributes. Color keys were employed to identify significant Spearman's correlation “r” indices at p < 0.05, referred as positive (red scale, , r(+) ranging from 0.5 to 1.0) or negative (green scale, , r(-) ranging from −1.0 to −0.5). Non-significant correlations are represented by white dots. Ratio between positive and negative correlations “r(+)/r(-)” are provided in the Figure. The common correlations across distinct 17DD-YF vaccine doses are highlighted by orange frames.