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. 2019 Apr 3;27(5):682–693. doi: 10.1016/j.jsps.2019.04.003

Scheme 1.

Scheme 1

Synthesis of 5,5-diphenylimidazolidine-2,4-dione conjugated to isatin, benzaldehyde or 3-formylindole. Reagents and conditions: (a) ethyl bromoacetate, K2CO3, acetone, reflux, 24 h; (b) N2H4, EtOH, rt, 24 h; (c) appropriate benzaldehyde or isatin, AcOH, MeOH, reflux, 6 h.