Table 1.
Putative novel resistance genes and gene variants detected in integron gene cassettes
| Gene name | Length (amino acid) | Closest homologue in NCBI protein database | Identity (%) | Accession number | Resistance against |
|---|---|---|---|---|---|
| aadA- like-1 | 288 | Aminoglycoside adenyltransferase, partial [Escherichia coli] | 89 | AEG64741.1 | Aminoglycosides |
| sat-like-1 | 301 | Streptomycin 3-adenylyltransferase [Yersinia pestis biovar Orientalis str. IP275] | 94 | EDR32758.1 | Aminoglycosides |
| aadA- like-2 | 287 | Aminoglycoside adenyltransferase, partial (plasmid) [Escherichia coli] | 94 | AIL81899.1 | Aminoglycosides |
| CAT-like | 170 | Chlor_Acetyltrans_CAT, partial [uncultured bacterium] | 92 | AMP56890.1 | Amphenicols |
| blaRSA1* | 270 | Class A extended-spectrum beta-lactamase BEL-1 [Pseudomonas aeruginosa] | 53 | WP_063857830.1 | Beta-lactams |
| OXA-like-1 | 300 | Class D [uncultured bacterium] | 87 | AMP47162.1 | Beta-lactams |
| OXA-like-2 | 266 | Class D [uncultured bacterium] | 91 | AMP48561.1 | Beta-lactams |
| OXA-like-3 | 266 | Oxacillin-hydrolyzing class D beta-lactamase OXA-10 [Gammaproteobacteria] | 92 | WP_000846390.1 | Beta-lactams |
| OXA-like-4 | 266 | Oxacillin-hydrolyzing class D beta-lactamase OXA-119 [Pseudomonas aeruginosa] | 93 | WP_032490445.1 | Beta-lactams |
| AmpC-like-1 | 329 | Beta-lactamase [Vibrio cholerae non-O1/non-O139] | 94 | BAE71359.1 | Beta-lactams |
| OXA-like-5 | 275 | Oxacillin-hydrolyzing class D beta-lactamase OXA-2 [Proteobacteria] | 95 | WP_001007673.1 | Beta-lactams |
| IMP-like-1 (IMP-81) | 246 | Subclass B1 metallo-beta-lactamase IMP-15 [Pseudomonas aeruginosa] | 96 | WP_063860575.1 | Beta-lactams |
| qacE-like-1 | 110 | QacE [uncultured bacterium] | 81 | ACN22612.1 | Disinfectants |
| qacG-like-1 | 96 | QacG, partial [uncultured bacterium] | 90 | ACS73614.1 | Disinfectants |
| arr-like-1 | 150 | NAD(+)--rifampin ADP-ribosyltransferase Arr-6 [Pseudomonas aeruginosa] | 86 | WP_063842214.1 | Rifampicin |
| sul4 # | 280 | Dihydropteroate synthase [Ardenticatena] | 68 | CUS02277.2 | Sulfonamides |
| Dfr-like 1 | 107 | Dihydrofolate reductase [Pseudomonas aeruginosa] | 88 | BAT62904.1 | Trimethoprim |
| Dfr-like 2 | 157 | Dihydrofolate reductase, partial [Vibrio cholerae] | 89 | AAT37842.1 | Trimethoprim |
*The sequence is 100% identical to blaRSA1
#The sequence is 100% identical to sul4