Table 2.
Additional criteria considered for orphan drugs framework
| Criteria | Type of criteria (quantitative/qualitative) | Source |
|---|---|---|
| Size of affected population | Quantitative | Previous study [7] |
| Preventive benefit | Quantitative | Previous study [7] |
| Therapeutic benefit | Quantitative | Previous study [7] |
| Non-medical costs | Quantitative | Previous study [7] |
| Budget Impact | Quantitative or qualitative | EVIDEM framework v.4 [8] and SLR [3] |
| Rarity | Quantitative or qualitative | SLR [3] |
| The rule of rescue | Quantitative or qualitative | SLR [3] |
SLR Systematic Literature Review