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. 2019 Jun 27;19:40. doi: 10.1186/s12896-019-0535-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Comparison of the VARSCOT pipeline (a) Receiver Operating Characteristic (ROC) curves of VARSCOT and other off-target activity models tested on the Test Dataset. b Number of potential off-targets detected by the VARSCOT, Elevation and CRISPOR pipelines compared to the off-targets detected experimentally in the Test Dataset. c Effect of a threshold on the True Positive Rate (TPR) and False Positive Rate (FRP) of detection of VARSCOT