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. 2019 Jun 27;17:212. doi: 10.1186/s12967-019-1961-9

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Mapping the likely outcomes of the mutation (p.Q518X) on the structure of the MutSalpha DNA lesion recognition complex. a The association between MSH6 and MSH2 proteins which dimeric form is capable of recognizing the damaged DNA is called MutSalpha. b Corresponds to the MSH2 protein in which we mapped the function segments downstream the stop codon insertion in dark blue. This results in loss of interaction between the two proteins (MSH2/MSH6) and a default of heterodimer formation (protein-protein interaction loss, DNA-protein interaction loss and nuclear translocation activity loss)