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. 2019 Jun 28;18:146. doi: 10.1186/s12944-019-1088-2

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Scheme of the drug application for the treatment in Npc1^+/+ and Npc1^−/− mice (a). Evaluation of spleen-to-body-weight ratios (SW/BW) of sham-treated Npc1^+/+ (n = 11), sham-treated Npc1^−/− (n = 9), treated Npc1^+/+ (n = 14), and treated Npc1^−/− mice (n = 12, b). Note the increase of SW/BW ratio of treated Npc1^+/+ and treated Npc1^−/− mice. Values are given as mean ± SEM; ANOVA; multiple comparison tests: *p ≤ 0.05 sham-treated Npc1^+/+ vs. treated Npc1^+/+; **p ≤ 0.01 sham-treated Npc1^+/+ vs. treated Npc1^−/−