Fig. 5.

Zero-order network formed by genes that are differentially expressed in histologically normal benign (HNB) and AH tissues. A network of protein interactions was constructed using 812 genes that were differentially expressed between AH and HNB tissues. The ERB-B genes (ERBB2, ERBB3, ERBB4, EGFR) define a central node connected to three major nodes associated with elevated expression of ESR1, AR, and ROHB in AH compared to HNB tissues. The data are presented as ratios with red indicating increased expression in AH tissues compared to HNB. Dotted lines encompassing major nodes indicate zero-order subnetworks