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. 2019 Jun 27;7:163. doi: 10.1186/s40425-019-0625-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Clinical trial design. The schema for the clinical trial is shown in a. The zones for dose escalation of LPS in cohort 1 (A-F) are shown in b. The study combinations are numbered c1 - c12 for cohort 1 and c21-c23 for cohort 2 as shown