Table 2.
Presurgery in vitro spiking of aPCC.
| TGA values | Baseline | aPCC (0.05 IU/ml) |
aPCC (0.1 IU/ml) |
aPCC (0.2 IU/ml) |
aPCC (0.3 IU/ml) |
aPCC (0.5 IU/ml) |
aPCC (0.75 IU/ml) |
Pooled normal plasma* |
|---|---|---|---|---|---|---|---|---|
| Lagtime_(min) | 7.55 | 4.67 | 4 | 3.33 | 3.33 | 3 | 2.67 | 7.67 |
| ETP_(nM•min) | 491.52 | 634.95 | 975.76 | 1476.13 | 1837.95 | 2596.55 | 2980.33 | 714.63 |
| Peak_(nM) | 36.59 | 40.07 | 70.32 | 135.15 | 185.7 | 283.04 | 381.6 | 69.61 |
| ttPeak_(min) | 17.69 | 15.11 | 13 | 10.22 | 9 | 7.33 | 6.33 | 12.67 |
| VelIndex_(nM/min) | 3.61 | 3.84 | 7.81 | 19.63 | 32.77 | 65.32 | 104.07 | 13.92 |
aPCC, activated prothrombin complex concentrate; ETP, endogenous thrombin potential; TGA, thrombin generation assay; ttPeak, time to peak; VelIndex, velocity index.
*
The pooled normal plasma results in our lab are different than previously reported with lower peak thrombin and ETP in particular. This is due to the different reagents and methods used by the different labs. Our lab follows the manufacturer’s instructions explicitly.