Table 3.
Presurgery in vitro spiking of porcine FVIII.
| TGA values | Baseline | Porcine FVIII (50 IU/ml) |
Porcine FVIII (100 IU/ml) |
Porcine FVIII (200 IU/ml) |
Pooled normal plasma* |
|---|---|---|---|---|---|
| Lagtime_(min) | 7.55 | 5.21 | 4.65 | 7.55 | 7.67 |
| ETP_(nM•min) | 491.52 | 1960.71 | 1818.57 | 1772.51 | 714.63 |
| Peak_(nM) | 36.59 | 422.24 | 349.62 | 312.85 | 69.61 |
| ttPeak_(min) | 17.69 | 7.21 | 6.65 | 9.77 | 12.67 |
| VelIndex_(nM/min) | 3.61 | 210.53 | 174.32 | 141.26 | 13.92 |
ETP, endogenous thrombin potential; TGA, thrombin generation assay; ttPeak, time to peak; VelIndex, velocity index.
*
The pooled normal plasma results in our lab are different than previously reported with lower peak thrombin and ETP in particular. This is due to the different reagents and methods used by the different labs. Our lab follows the manufacturer’s instructions explicitly.