Figure 3.
(A) SorbC substrates including native substrate 13 and substrates that are dearomatized with decreased stereoselectivity 21 and 22. (B) Homology model of SorbC (gray surface) with FAD (yellow sticks), and sorbicillin (13, blue) in the major pose observed in favorable docking solutions. (C) Impact of C1 substituent on SorbC activity. (D) Analysis of reactivity, kinetics, and binding of sorbicillin (13), methyl ester 26, and crotyl ester 27 with SorbC.