Figure 2.

Ponatinib reduces influenza A virus-induced mortality in mice. BALB/c mice of 6–8 weeks old were infected with 500 TCID₅₀ of influenza A virus (A/PR/8/34) by intranasally. Two hours later, 4 groups of mice (n = 10) were simultaneously treated orally with 25, 15, 5 mg/kg/d of ponatinib, or placebo. Survival rate (A) and body weight loss (B–D) were monitored daily until day 20 post-infection. The data are representative of at least three independent experiments.*p < 0.05; ***p <0.001.