Figure 3.

Delayed administration of ponatinib enhances protection against lethal infection in mice. (A) Experimental setup for optimization of drug administration timing. Mice were infected as described in Figure 2 but treated with ponatinib (15 mg/kg) starting on days 1, 2, 3, or 4 post-infection until day 6 post-infection. Survival rate (B) and weight loss (C–F) were monitored daily until day 20 post-infection. The data are representative of at least three independent experiments. *p < 0.05; **p < 0.01; ***p <0.001.