Figure 4.

Ponatinib suppresses neutrophils infiltration in the lungs of mice with lethal infection. Mice were infected as described in Figure 2. Starting with day 3, daily administration of placebo or ponatinib (15 mg/kg) was given orally. (A) Hematoxylin & eosin-stained mouse lung sections (scale bar 200 μm) harvested at day 7 post-infection. (B) BALFs were collected from placebo and ponatinib-treated mice (n = 3 per group at each time point) starting day 3 post-infection to monitor total cell counts (mean ± SEM) on days 5 and 7 post-infection. The data are representative of at least three independent experiments.*p < 0.05; **p < 0.01.