Figure 2.

The synthesis of CA after genetic modification in strains of E.coli that allowed the production of two enzymes: 3-hydroxylase hydroxyphenylacetate (4HPA3H) and tyrosine ammonia lyase (TAL) that act on L-tyrosine producing p-coumaric acid and L-dopa, respectively. A new action of these enzymes on the two intermediate molecules leads to production of CA. This figure was made with ChemDraw (http://www.perkinelmer.com/category/chemdraw).