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. 2019 Jun 21;13:275. doi: 10.3389/fncel.2019.00275

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Copyright © 2019 Zhou, Xue, Xue, Sang, Liu, Wang, Cai, Zhang, Tan, Wang and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Electroacupuncture pretreatment improved hippocampal neurogenesis and the expression of BDNF, DCX, and Nrf2 and their related genes in ESPS-treated rats. (A) Microphotographs and (B,C) histograms of BrdU-positive proliferating cells and of the DCX-positive immature neurons in the dentate gyrus. (D–H) Representative immunoblots and densitometry analysis of (D) DCX, (E) BDNF, (F) p-AMPK, (G) Nrf2, and (H) HO-1 expression in the total hippocampus of control, EA, ESPS, and EA + ESPS groups. ^∗P < 0.05, ^#P < 0.05 vs. ESPS, ^##P < 0.01 vs. ESPS. Bar: 100 μm.