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—An example of the rewiring of a gene regulatory network where a DNA-binding protein (black circles) regulates a number of genes (blue rectangles) by binding to DNA motifs (black stripes). Some of the motifs and binding events may be lost (represented by gray stripes and circles), whereas new motifs and binding events may appear, which can sometimes wire new genes into the network. TEs (gray rectangles) may play an important role in providing and dispersing these new motifs.
