Morphology and characterization of CDs-ICG-LPs. (A) TEM images of CDs-DOX and CDs-ICG-LPs with or without continuous laser irradiation. After laser irradiation CDs-ICG-LPs were broken up into smaller pieces with heat-induced disruption. (B) Absorption and fluorescence spectrum of ICG, CDs-DOX, and CDs-ICG-LPs. (C) FL stability of free ICG, CDs-DOX, and in CDs-ICG-LPs. (D) Maximum temperature profiles of free ICG, ICG-LPs, CDs-ICG-LPs, and PBS as a function of the irradiation time under continuous laser irradiation at a power intensity of 2 W/cm2. (E) DOX release profiles from CDs-ICG-LPs with and without laser irradiation at pH 7.4 or pH 5.5. The data are shown as mean. It was consistent with the in vitro release experiments that the DOX release of CDs-ICG-LPs could be accelerated by laser irradiation. (F) Infrared thermographic maps of centrifuge tubes with CDs-ICG-LPs, CDs-DOX, ICG-LPs, or PBS were measured at 5 min with an infrared thermal imaging camera after continuous laser irradiation.