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. 2019 Jun 27;8(1):1627164. doi: 10.1080/20013078.2019.1627164

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — The effect of brain tumour-derived EVs on immune cells. EVs derived from primary brain tumour cells can induce an M2 phenotype in microglia and decrease the cytotoxicity of the CD8 + T cells. Metastatic brain tumour EVs can activate microglia through the TLR receptor.