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. 2019 Jun 25;26(1):629–640. doi: 10.1080/10717544.2019.1628118

Figure 2.

Figure 2.

Construction and characterization of GNPs-adhered and PTX-PLGA-Ms (GNPs-PTX-PLGA-Ms). (A) Scanning electron microscopy (SEM) images showing the pD-coated PLGA-Ms. Under weak alkaline condition (0.01 M NaHCO3, pH 8.5), the catechol groups of DOPA can be oxidized to form quinone groups, followed by polymerization giving pD-coated PLGA-Ms. (B) TEM images of pD capsules. (C) TEM image of GNPs (scale bar: 80 nm). GNPs is synthesized using the Turkevich method. (D) TEM images showing the saturation of GNPs adhered to the surface of PTX-loaded PLGA-Ms. The catechol group of polydopamine (pD) chelate GNPs, and form the GNPs-PTX-PLGA-Ms complex. (E) Stability profile of GNPs-pD-PTX-PLGA-Ms after 24 h incubation in 0.01 M NaHCO3, DMEM, water.