Figure 1.

Characterization of conserved and variable blocks in aligned TSA56 sequences. The upper plot shows the moving mean, for a window of 10 amino acid residues, of the number of different amino acids observed at a position in the amino acid alignment using 206 tsa56 genes (list available at ref. 3). The overall average of sequence variation is noted by the red dashed line. The location of conserved (CB1 ∼ 7, blue) and variable blocks (VB1 ∼ 6, red) annotated in this study and the variable domains (VD1 ∼ 4, grey) defined in a previous work (ref. 12) is shown below the graph. SP, signal peptide.