Table 1.

Inhibition data of TcCA, LdCA and human CA I and II with sulfonamides reported here and the standard inhibitor acetazolamide (AAZ) by a stopped flow CO₂ hydrase assay.

Compound	R	KI (μM)a
		TcCA	LdCA	hCA I	hCA II
4		0.08	0.21	0.91	0.24
6		0.16	0.34	4.35	0.18
7		2.52	4.68	4.79	0.84
8		0.24	0.46	6.18	0.61
9	C6H5	3.54	3.87	1.38	0.39
10	4-F-C6H4	4.79	8.49	2.92	0.46
11		10.7	6.57	>50	1.81
12		0.11	0.39	6.21	0.64
13	C6H5	0.32	1.06	>50	2.78
14	4-F-C6H4	0.46	0.98	5.39	0.53
15	4-CF3-C6H4	0.51	2.34	5.20	0.24
16	4-F-3-CH3-C6H3	0.38	2.96	7.58	0.21
17	C6F5	0.28	1.36	0.69	0.27
18	3-CH3O-C6H4	0.91	0.95	8.21	5.15
19	3,4-(OCH2O)-C6H3	1.02	2.03	>50	4.33
20	3,5-CH3-C6H3	0.69	1.86	8.33	0.45
21	3,5-CF3-C6H3	1.35	3.65	5.99	1.72
22	CH2CH2C6H5	0.74	0.86	9.29	3.08
23	CH2-(2-furyl)	0.41	1.02	>50	2.53
24	2,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-3-yl	2.47	3.64	5.67	1.89
25	2,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yl	2.14	2.97	4.92	0.86
AAZ	–	0.06	0.09	0.25	0.012

^aMean from three different assays, by a stopped flow technique (errors were in the range of ±5–10% of the reported values).