Table 3.
Minimum inhibitory concentration (MIC), IC50 values derived from growth inhibition assays of T. cruzi Dm 28c and Y, determination of cytotoxicity (CC50), selectivity index (SI50) of compounds 4, 6, 8, 10, 11, 17, 18, 19, 21, and 24.
| Compound |
T. cruzi Dm 28c |
T. cruzi Y |
CC50 (µM)d | ||||
|---|---|---|---|---|---|---|---|
| MIC (µM)a | IC50 (µM)b | SIc | MIC (µM)a | IC50 (µM)b | SIc | ||
| 4 | >256 | n.d. | n.d. | >256 | n.d. | n.d. | 97.65 ± 11.13 |
| 6 | >256 | n.d. | n.d. | >256 | n.d. | n.d. | 100.21 ± 17.27 |
| 8 | >256 | n.d. | n.d. | >256 | n.d. | n.d. | >256 |
| 10 | >256 | n.d. | n.d. | >256 | n.d. | n.d. | 179.93 ± 21.31 |
| 11 | >256 | n.d. | n.d. | >256 | n.d. | n.d. | >256 |
| 17 | >256 | n.d. | n.d. | >256 | n.d. | n.d. | >256 |
| 18 | >256 | n.d. | n.d. | >256 | n.d. | n.d. | >256 |
| 19 | >256 | n.d. | n.d. | >256 | n.d. | n.d. | 172.65 ± 10.44 |
| 21 | >256 | n.d. | n.d. | >256 | n.d. | n.d. | >256 |
| 24 | >256 | n.d. | n.d. | >256 | n.d. | n.d. | >256 |
| Bzn | 32 | 16.56 ± 1.51 | 6.54 ± 1.82 | 32 | 18.45 ± 0.32 | 6.168 ± 0.81 | 115.14 ± 9.48 |
a
Minimum inhibitory concentration.
b
µM – concentration which reduced the proliferation of epimastigotes by 50%.
c
Selectivity index of 50% = CC50/IC50.
d
µM – concentration cytotoxic which reduced 50% of RAW 267.4 cells.