Table 2.

Tumour immune cell infiltration according to TP53 mutation status within the consensus molecular subtypes (Oslo series, N=316)

Cell population	CMS1 (n=62)		CMS2 (n=138)		CMS3 (n=54)		CMS4 (n=62)
	Mean difference*	Adjusted P value†	Mean difference*	Adjusted P value†	Mean difference*	Adjusted p value†	Mean difference*	Adjusted P value
T cells	0.52	0.005	−0.005	1.0	0.023	1.0	0.16	1.0
CD8 T cells	0.24	0.76	−0.055	1.0	0.06	1.0	0.24	0.16
Cytotoxic lymphocytes	0.59	0.002	0.023	1.0	0.084	1.0	0.20	1.0
NK cells	0.22	0.12	0.025	1.0	0.034	1.0	0.21	0.12
B lineage	0.14	1.0	−0.01	1.0	−0.19	1.0	0.37	1.0
Monocytic lineage	0.66	0.006	−0.098	1.0	0.082	1.0	0.32	1.0
Myeloid dendritic cells	0.31	0.03	−0.011	1.0	−0.04	1.0	0.21	1.0
Neutrophils	0.012	0.90	0.083	0.76	0.025	1.0	0.25	0.24
Endothelial cells	0.054	1.0	−0.12	0.96	0.011	1.0	0.09	1.0
Fibroblasts	0.14	1.0	−0.107	1.0	0.233	1.0	0.43	0.2

*Difference in abundances of eight immune and two stromal cell populations between TP53 wild-type and mutated tumours (positive values indicate higher infiltration in wild type), measured based on gene expression (Microenvironment Cell Populations-counter algorithm).

†Independent samples t-test. P values have been adjusted for multiple hypotheses testing according to Bonferroni (multiplied by 40), and adjusted p values <0.05 are highlighted in bold.

CMS, consensus molecular subtype.