Table 2.

Signature genes determined to be significant for the behavior of the network and used to reduce the stable states.

Gene	Note
BAMB1	Pseudoreceptor of the TGFβ pathway whose function might be to limit the signaling range of the TGFβ family.
CBLC	Member of the Cbl family of E3 ubiquitin ligases that plays an important role in cell signaling. Its expression might be restricted to epithelial cells.
EGFR	Receptor for members of the epidermal growth factor family.
ERBB2	Member of the epidermal growth factor receptor family. While it does not have a ligand binding domain it acts as a stabilizer for the interaction between other receptors and ligands of the same family. Overexpression of this gene has been reported in numerous cancers.
FOXO6	Transcription factor, generally localized in the nucleus and elevant marker for the regulation of cancer development (e.g., lung and gastric cancer), whose effect has been shown to be context dependent (Jacobs et al., 2003; Qinyu et al., 2013; Hu et al., 2015).
ITGB1	Membrane receptor involved in cell adhesion and a variety of processes like embryogenesis, tissue repair, immune response and metastatic diffusion of tumor cells.
MAPK1	Kinase that integrates multiple biochemical signals, and is involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development.
TLR2	Receptor involved in pathogen recognition and activation of the innate immunity.