Table 1:
Statistically over-represented biological processes, molecular functions, and signaling pathways for transcripts altered in CF reproductive tract.
| PANTHER GO-Slim Biological Process | Total in Rattus norvegicus (of 23781) | Expected out of 72 | No. out of 72 significantly altered | Fold Enrichment | P-value (Bonferoni corrected) |
|---|---|---|---|---|---|
| Muscle organ development (GO:0007517) | 250 | 0.74 | 8 | 10.87 | 0.00019 |
| Developmental process (GO:0032502) | 1951 | 5.74 | 19 | 3.31 | 0.000582 |
| Ectoderm development (GO:0007398) | 399 | 1.17 | 9 | 7.66 | 0.000656 |
| System development (GO:0048731) | 1051 | 3.09 | 13 | 4.2 | 0.00262 |
| Muscle contraction (GO:0006936) | 158 | 0.47 | 5 | 10.75 | 0.0264 |
| Nervous system development (GO:0007399) | 667 | 1.96 | 9 | 4.58 | 0.0359 |
| Protein ADP-ribosylation (GO:0006471) | 6 | 0.02 | 2 | > 100 | 0.0366 |
| PANTHER GO-Slim Molecular Function | Total in Rattus norvegicus (of 23781) | Expected out of 72 | No. out of 72 significantly altered | Fold Enrichment | P-value (Bonferoni corrected) |
| Sequence-specific DNA binding transcription factor activity (GO:0003700) | 1263 | 3.72 | 14 | 3.77 | 0.00286 |
| DNA binding (GO:0003677) | 1542 | 4.54 | 14 | 3.08 | 0.0247 |
| PANTHER Pathways | Total in Rattus norvegicus (of 23781) | Expected out of 72 | No. out of 72 significantly altered | Fold Enrichment | P-value* |
| Histidine biosynthesis (P02747) | 2 | 0.01 | 1 | > 100 | 0.00587 |
| Cadherin signaling pathway (P00012) | 151 | 0.44 | 3 | 6.75 | 0.0102 |
| Wnt signaling pathway (P00057) | 314 | 0.92 | 4 | 4.33 | 0.014 |
| Gamma-aminobutyric acid synthesis (P04384) | 6 | 0.02 | 1 | 56.62 | 0.0175 |
| Vitamin D metabolism and pathway (P04396) | 16 | 0.05 | 1 | 21.23 | 0.046 |
*
p-values for “PANTHER Pathways” not Bonferoni corrected due to the large number of tests performed.