Table 2.

Main pharmacokinetic parameters of different tilmicosin dosages in the in vitro PK/PD model.

Pharmacokinetic parameters	Dose group (mg)							$\overline{X}$	Relative deviation %
	1	2.5	5	7.5	10	15	20
D (mg)	0.089	0.223	0.446	0.670	0.893	1.339	1.786	–	–
t1/2Ka (h)	5.24	4.71	4.66	5.63	5.16	5.80	5.58	5.25	6.18%
t1/2Kel (h)	40.18	44.25	43.11	41.37	41.99	39.75	39.92	41.51	3.08%
Tmax (h)	17.72	17.03	16.77	18.74	17.79	18.86	18.41	18.41	0.32%
Cmax (µg/ml)	0.11	0.29	0.60	0.98	1.29	1.84	2.67	–	–
VCentral (mL)	574.95	584.19	563.50	500.08	515.99	487.29	485.34	530.19	6.04%
R2	0.997	0.993	0.999	0.997	0.998	0.996	0.997	–	–

Relative deviation = (PK parameters in vitro/PK parameters in vivo—1) * 100%; –, no data.