Table 2.

Reactions modelled in the InsulinSignallingModel.ka file.

Reaction name in the model	Reaction details
ins_insr_binding	Binding between insulin and the alpha subunit of the insulin receptor [8]
insr989_autophos, insr1175_autophos, insr1179_autophos, insr1180_autophos	Autophosphorylation of Insr at sites Y989, Y1175, Y1179 and Y1180, respectively [9]
insr_irs1_binding	Binding of Irs1 to Insr [9]
irs1_y460, irs1_y608, irs1_y628, irs1_y891, irs1_y935, irs1_y983, irs1_y1171, irs1_y1218	Phosphorylation of Irs1 at sites Y460 [10], Y608 [10], Y628 [10], Y891 [11], Y935 [10], Y983 [10], Y1171 [11] and Y1218 [11], respectively, by Insr
irs1_grb2	Binding of Irs1(at Y891) and grb2 [11], [12]
shc1_y423	Shc1 Y423 phosphorylation by Insr [13]
shc1_grb2	Phosphorylated Sch 1 at Y423 binding to Grb2 [12]
grb2_sos	Grb2 (bound to shc1) binding to Sos [14]
sos_GDP	When Grb2 bound to Shc1, GDP bound to Ras unbinds [14]
ras_GTP	Ras binding to GTP [14]
ras_raf1	Ras is binding to Raf1 [14]
map2k1_s218, raf1_map2k1	Phosphorylation of Map2k1 at sites S218 and S222, respectively, by raf1 [15]
map2k2_s222, raf1_map2k2	Phosphorylation of Map2k2 at sites S222 and S226, respectively, by raf1 [15]
erk1_t203, erk1_y205, erk2_t183, erk2_y185	Phosphorylation of Erk1 and Erk2 at sites T203 and Y205, and T183 and Y185 respectively, by Map2k1 [2]
erk1_t203_b, erk1_y205_b, erk2_t183_b, erk2_y185_b	Phosphorylation of Erk1 and Erk2 at sites T203 and Y205, and T183 and Y185 respectively by Map2k2 [2]