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. 2019 Jun 28;10:2892. doi: 10.1038/s41467-019-10769-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Human ulcerative colitis transcriptional signature does not cluster patients into molecular profiles. a Schematic representation of the strategy used for patient group identification, in which four publicly available data sets were combined. Gene ranking was done using the most variable genes in the human data set, which were used for clustering analysis. b Sample dissimilarity heatmaps for visual analysis of clustering tendency (VAT), comparing the human data set using the top 100 variable genes. c t-SNE plot using the top 100 variable genes in the human data set. Each point represents a patient sample. d Hartigan’s Dip test for clustering tendency using all genes in the data set, the top 100 variable genes, the top 100 highly dispersed genes, or the top 100 leading genes in the principal components. e Bootstrapping analysis of hierarchical clustering, comparing the human data set using the top 100 variable genes in the human data set. Numbers in orange indicate the approximately unbiased (AU) p-value, shown as a percentage. AU closer to zero indicates a cluster with low stability. Boxplot represents the median (center line, second quantile), first, and third quantiles (box) and whiskers extending 1.5 times the interquartile range (IQR)