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. 2019 Jun 28;9:9388. doi: 10.1038/s41598-019-45858-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overview of exclusion criteria for Maastricht Study data and results of analysis in PRESERVE and Maastricht studies. (a) Flow chart of exclusion of data from the Maastricht Study for analysis. (b) Bar plots of time of glucose peak in Maastricht study OGTT data, white bars show seven time point data; black bars indicate the five time point subset. Dashed line shows distribution of peak glucose time predicted by cubic splining of five time point data. (c) dG/dt five (dashed line) computed on a five time point subset (black circles) differs from dG/dt seven (dot-dashed line) computed on a seven time point OGTT (black circles plus empty circles). dG/dt spline (dotted line) computed on a cubic spline of the five time point data (solid line) more closely represents the seven time point dG/dt. (d) Scatter plot of PRESERVE Study (n = 69) clamp ssGIR with both the standard MISI (open circles) and cubic spline MISI (crosses). Correlation for standard MISI and modified MISI with ssGIR value are represented by the solid and dashed lines of best fit respectively.