Table 1.

Spearman correlations and reclassification probabilities for MISI computed using both the standard and modified methods on OGTT data for various common sampling schedules.

Correlation	Maastricht Study (n = 1891)				PRESERVE Study (n = 66)
	5 time point MISI		7 time point MISI		5 time point MISI		clamp ssGIR
time points	standard	modified	standard	modified	standard	modified	standard	modified
4 (30, 60, 90, 120)	0.999	0.945	0.924	0.819	0.999	0.944	0.473	0.457
4 (0, 60, 90, 120)	0.928	0.881	0.878	0.794	0.897	0.826	0.440	0.464
4 (0, 30, 90, 120)	0.817	0.842	0.775	0.763	0.831	0.852	0.356	0.618
4 (0, 30, 60, 120)	0.790	0.703	0.748	0.664	0.886	0.755	0.481	0.661
5 (0, 30, 60, 90, 120)	1	1	0.925	0.864	1	1	0.475	0.561
Reclassification	5 time point MISI		7 time point MISI		5 time points MISI		clamp ssGIR
time points	standard	modified	standard	modified	standard	modified	standard	modified
4 (30, 60, 90, 120)	0.015	0.202	0.151	0.277	0.030	0.152	0.470	0.576
4 (0, 60, 90, 120)	0.160	0.216	0.202	0.302	0.106	0.212	0.515	0.485
4 (0, 30, 90, 120)	0.326	0.292	0.348	0.347	0.349	0.227	0.500	0.485
4 (0, 30, 60, 120)	0.331	0.406	0.365	0.412	0.167	0.333	0.591	0.394
5 (0, 30, 60, 90, 120)	0	0	0.145	0.220	0	0	0.485	0.485

First two columns show comparison with MISI computed on five and seven time points within the Maastricht Study (n = 1891). The second two columns show comparison with MISI computed on five time points and the steady state glucose infusion rate of the hyperinsulinemic-euglycaemic clamp (ssGIR) for individuals within the PRESERVE Study. The upper half of the table shows correlation coefficients computed by Spearman correlation, the lower section shows net reclassification probabilities.