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. 2019 Jun 28;9:8584. doi: 10.1038/s41598-019-44688-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of the designed peptide DP6 on 1D sliding of the p53 tetramer along DNA. (a) Schematic diagram of the single-molecule detection of p53 labeled with Atto532 on a DNA array. Yellow circles, pink circles, and solid lines represent NeutrAvidin, p53, and DNA, respectively. (b) Typical single-molecule trajectories of FL-p53 along nonspecific DNA at various DP6 concentrations. Several traces are colored for clarity. (c) Time courses of the averaged MSD of FL-p53 at various DP6 concentrations. (d) Displacement distributions for the sliding dynamics of FL-p53 at various DP6 concentrations. Bars represent the displacement distributions observed at time intervals of 165 ms. Errors of the bar were estimated by a bootstrap method with 1,000 iterations. Solid and dashed curves are best-fitted curves obtained using Equation (3) described in Methods and the distributions of each mode, respectively.