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. 2019 Jun 28;10:2869. doi: 10.1038/s41467-019-10732-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Analysis of ptox locus and paraclostridial mosquitocidal protein 1 (PMP1) sequences. a Map of the 109 kb megaplasmid in Paraclostridium bifermentans subsp. malaysia (Pbm) and Pb paraiba (Pbp). b Configuration of clostridial neurotoxin loci in different Clostridium and non-Clostridium strains and in Pbm. c Phylogenetic split network covering all botulinum neurotoxin (BoNT) serotypes, subtypes, mosaic toxins, and tetanus neurotoxin (TeNT). PMP1 is in bold. The scale bar represents the split support for the edges⁴⁷. d Schematic drawing of the three domains of PMP1 showing the conserved elements found in clostridial neurotoxins: HELXH motif in the light chain (LC), the cysteines that form disulfide bond between LC and heavy chain (HC) and the tandem SxWY motif in the HC