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. 2019 Jun 28;9:172. doi: 10.1038/s41398-019-0506-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Here we show only the statistically significant effects of treatment (nodes without asterisk) and interaction of group and treatment (nodes with asterisk) on nodal strength from two-way ANOVA test. The effect of treatment (ketamine) had same direction in the NC and PC rats, whereas the effect of interaction of group and treatment had an opposite direction (for those cases we illustrate the direction in the NC group). Sphere color represents the F-statistic values from two-way ANOVA test for effects of treatment and interaction. The presence of connections (lines) between brain regions illustrate whether there was a change in inter-nodal correlation coefficients after ketamine in the NC rats versus saline condition. See legend of Fig. 2 for the abbreviations of brain regions