Table 1.

Characteristics of SNPs used as instrumental variables.

Locus	SNP	Chr	IL18 increasing Allele	Allele Frequency	IL18 Resultsa		IBD Resultsb
					Effect on IL18 (SD)	p-value	OR (95% CI)	p-value
NLRC4	rs385076	2	C	0.64	0.243	1.7 × 10−22	1.05 (1.02–1.09)	0.0051
OCLN	rs17229943	5	C	0.05	0.312	1.6 × 10−11	1.07 (0.97–1.18)	0.066
IL18	rs71478720	11	C	0.76	0.267	3.1 × 10−22	1.05 (1.01–1.09)	0.012

^aeffect size and p-value selected from the cytokine GWAS¹⁷.

^bOR (95% CI) and p-value selected from the IBDGenetics Consortium⁶.