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. 2019 Jun 28;9:9405. doi: 10.1038/s41598-019-45795-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic illustration of proteins used as targeting vehicles for molecular imaging. (A) Structures of an IgG monoclonal antibody sized relative to a DARPin G3. (B) Four DARPin G3 variants having histidine-containing tags at N-terminus or C-terminus were used in this study. Illustrations were taken from Research Collaboratory for Structural Bioinformatics Protein Data Bank: 1IGT (antibody), 2JAB (DARPin).