Table 5.
Tumor-to-organ ratios for 99mTc-labeled G3 variants in BALB/C nu/nu mice bearing SKOV3 xenografts at 4 and 24 h pi.
| [99mTc]Tc(CO)3-H6-G3 | [99mTc]Tc(CO)3-G3-H6 | [99mTc]Tc(CO)3-(HE)3-G3 | [99mTc]Tc(CO)3-G3-(HE)3 | |
|---|---|---|---|---|
| 4 h | ||||
| Blood | 46 ± 20c | 54 ± 7e | 49 ± 10f | 19 ± 2 |
| Salivary glands | 5 ± 2 | 5 ± 2 | 13 ± 4b,d,f | 6 ± 1 |
| Lung | 18 ± 7 | 11 ± 3 | 26 ± 3d,f | 12 ± 2 |
| Liver | 1.6 ± 0.7 | 1.8 ± 0.3 | 4.9 ± 0.3b,d,f | 2.2 ± 0.3 |
| Spleen | 10 ± 4 | 7 ± 2 | 19 ± 2b,d,f | 7 ± 1 |
| Stomach | 12 ± 5 | 9 ± 2 | 23 ± 6b,d,f | 10.2 ± 0.2 |
| Kidney | 0.03 ± 0.01 | 0.04 ± 0.01 | 0.037 ± 0.004 | 0.03 ± 0.01 |
| Muscle | 42 ± 20 | 26 ± 6 | 80 ± 5b,d,f | 29 ± 4 |
| Bone | 10 ± 4 | 9 ± 3 | 25 ± 4b,d,f | 10 ± 2 |
| 24 h | ||||
| Blood | 110 ± 12a,c | 83 ± 11e | 80 ± 6b,f | 32 ± 7 |
| Salivary glands | 8 ± 1 | 4 ± 2 | 16 ± 3b,d,f | 6 ± 1 |
| Lung | 25 ± 5a,c | 17 ± 3 | 28 ± 2d,f | 12 ± 2 |
| Liver | 2.3 ± 0.6 | 2.3 ± 0.6 | 5.9 ± 0.9b,d,f | 1.8 ± 0.4 |
| Spleen | 10 ± 3 | 8 ± 1 | 20 ± 3b,d,f | 6 ± 2 |
| Stomach | 21 ± 4 | 12 ± 3 | 32 ± 7b,d,f | 12 ± 3 |
| Kidney | 0.045 ± 0.002 | 0.04 ± 0.01 | 0.05 ± 0.01f | 0.03 ± 0.01 |
| Muscle | 51 ± 16c | 30 ± 15 | 84 ± 5b,d,f | 24 ± 7 |
| Bone | 16 ± 3 | 11 ± 5 | 24 ± 10d,f | 6 ± 2 |
One-way ANOVA with Bonferroni’s multiple comparisons test was performed to find significant differences. aSignificant difference between [99mTc]Tc(CO)3-H6-G3 and [99mTc]Tc(CO)3-G3-H6. bSignificant difference between [99mTc]Tc(CO)3-H6-G3 and [99mTc]Tc(CO)3-(HE)3-G3. cSignificant difference between [99mTc]Tc(CO)3-H6-G3 and [99mTc]Tc(CO)3-G3-(HE)3. dSignificant difference between [99mTc]Tc(CO)3-G3-H6 and [99mTc]Tc(CO)3-(HE)3-G3. eSignificant difference between [99mTc]Tc(CO)3-G3-H6 and [99mTc]Tc(CO)3-G3-(HE)3. fSignificant difference between [99mTc]Tc(CO)3-(HE)3-G3 and [99mTc]Tc(CO)3-G3-(HE)3.