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. 2019 Jun 28;9:9380. doi: 10.1038/s41598-019-45260-6

Figure 4.

Figure 4

TLR4 mediates LPS-induced activation of CD4+ T lymphocytes: (a) Quantification of the number of activated TLR4−/− CD4+ T lymphocytes in the presence of LPS. (b) Representative image of the effect of LPS on the activation of TLR4−/− CD4+ T cells. (c) Quantification of the numbers of IFNγ- and IL-2- producing TLR4-deficient CD4+ T lymphocytes in presence of LPS. (d) Quantification of the number of activated WT CD4+ T cells stimulated with or without CLI-095. (e) Quantification of the number of activated WT CD4+ T cells stimulated with LPS in presence or absence of CLI-095. Two-way ANOVA with Sidak post-test was used (a,c–e). Data are means ± SEM from three experiments. ns = not significant, ****p < 0.0001.