Fig. 1.

( A ) Recovery in platelet count in an autoimmune HIT after transcatheter aortic valve. (B) The impact of IVIG on platelet activation by autoimmune HIT antibodies. Patient's serum was incubated with platelets from four healthy donors in the presence of 0.2 IU/mL LMWH (reviparin) and different concentrations of IVIG. Platelet activation was determined by measurement of time until platelet aggregation in the HIPA assay. DAPT, dual antiplatelet therapy; DOAC, direct oral anticoagulant; HIT, heparin-induced thrombocytopenia; IVIG, intravenous immunoglobulin; LMWH, low-molecular-weight heparin; MAb IV.3, Fc gamma receptor IIa blocking monoclonal antibody.