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. 2019 Jun 28;10:2871. doi: 10.1038/s41467-019-10752-6

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Fig. 4 — Structure of the central domain. a A123 stacks with and caps the proximal end of the tetrastem. b Interactions between A123 and G106 connects the tetrastem to the central domain. c Effects of A123 and G106 substitutions on PKR inhibition. d–f Structure of the Loop 8–Loop 10 pseudoknot and interactions with A36. g Effects of A36 and G127 substitutions on PKR inhibition. h Effects of pseudoknot disruptions on PKR inhibition. i Effects of Stem 7 alterations on PKR inhibition. Three mismatches in Stem 7 (G97U::G99U::G110U) abrogated PKR inhibition while ΔU115 enhanced VA-I potency. Error bars represent s.d. from three independent replicates